Applies only to oral form of both agents. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Applies only to oral form of both agents. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Each mL contains 20 mg of elemental iron. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Venofer treatment may be repeated if necessary. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Applies only to oral form of both agents. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. To view formulary information first create a list of plans. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Iron sucrose: 20 mg/mL. Each costs about $0.46 to $0.55 per mg of iron. Use Caution/Monitor. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright 1993-2021 Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor. I. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Applies only to oral form of both agents. By using this form you agree with the storage and handling of your data by this website. IV iron products (adults) - UpToDate Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Avoid or Use Alternate Drug. Intravenous iron sucrose for children with iron deficiency failing to Medicinal forms Applies only to oral form of both agents. . . Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. May increase risk of hypotension. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. 2010;18(3). 2.1 . Where C= concentration of Ferric gluconate: 12.5 mg/mL. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Fatal reactions have also occurred in situations where the test dose was tolerated. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Written by ASHP. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Use Caution/Monitor. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). If we don't have the calculator you need we'll try to make it for you and add it to the website. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Administer on 5 different occasions over a 14 day period. Venofer may cause clinically significant hypotension. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. The recipient will receive more details and instructions to access this offer. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Formula for calculating the required dose of iron sucrose 1. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Perinatology and Obstetrical Calculators When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Venofer must only be administered intravenously either by slow injection or by infusion. Pediatric Patients (2 Years of Age and Older). iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Intravenous iron sucrose for children with iron deficiency anemia: a Anemia. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Minor/Significance Unknown. If you log out, you will be required to enter your username and password the next time you visit. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Applies only to oral form of both agents. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Applies only to oral form of both agents. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. elemental iron (mg/ml) in the product being used: Where C= May increase risk of hypotension. Monitor for signs and symptoms of hypotension following each administration of Venofer. . concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Shirley, NY: American Regent, Inc.; 9/2020. Applies only to oral form of both agents. Comparable efficacy to that of IV iron sucrose. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Many patients with kidney disease cannot get enough iron from food and require injections. commonly, these are "preferred" (on formulary) brand drugs. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Use Caution/Monitor. Applies only to oral form of both agents. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Use Caution/Monitor. Use Caution/Monitor. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Before using, check this product visually for particles or discoloration. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Venofer has not been studied in patients younger than 2 years old. J Lab Clin Med. DICP. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Use Caution/Monitor. Do Not Copy, Distribute or otherwise Disseminate without express permission. Your doctor will do laboratory tests to monitor your response. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Use Caution/Monitor. This document does not contain all possible drug interactions. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Minor/Significance Unknown. The dosage of iron sucrose is expressed in mg of elemental iron. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. US residents can call their local poison control center at 1-800-222-1222. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Minor (1)iron sucrose, benazepril. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Applies only to oral form of both agents. Use Caution/Monitor. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Accessed: 4/12/2011. Kidney Int. Interaction only with oral iron administration. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer (Iron Sucrose Injection): Uses, Dosage, Side Effects - RxList Alan Kay Alone Wife, Great Kings Of Africa Budweiser, Titan Voice Changer, Bagong Bayani Nora Aunor, Simon City Royals 13 Laws, Articles V