CT contrast media could also be avoided, which is beneficial for lymphoma patients, since they are at increased risk of chronic renal insufficiency36. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. Cancer Res. Among the scans that showed discordance, 24 scans scored DS 4/5 were continued on the same treatment regimen and the next assessment showed disease progression. Ng, A.K. This site needs JavaScript to work properly. Epub 2017 Dec 10. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. https://doi.org/10.1038/nrclinonc.2017.141 (2017). The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Careers. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1-3) compared with 43 (75.4%; 90% CI, 64.3% to 84.5%) of 57 in the ABVD arm. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" https://doi.org/10.1007/s00259-014-2715-9 (2014). The statistical analysis involved several steps. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. In the meantime, to ensure continued support, we are displaying the site without styles https://doi.org/10.1007/s11307-022-01703-7 (2022). Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. Google Scholar. Methods 188, 2029. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. Med. Ganeshan et al. Usually, the target lesion was the one with the visually highest DS. ; Hautzel, H. FDG-PET response prediction in pediatric Hodgkins lymphoma: Impact of metabolically defined tumor volumes and individualized SUV measurements on the positive predictive value. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). 8600 Rockville Pike Purpose Recent advances in imaging, use of prognostic indices, and molecular profiling techniques have the potential to improve disease characterization and outcomes in lymphoma. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. 14, 749762. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. government site. Biggi, A.; Gallamini, A.; Chauvie, S.; Hutchings, M.; Kostakoglu, L.; Gregianin, M.; Meignan, M.; Malkowski, B.; Hofman, M.S. It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. Internet Explorer). Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. Early and late therapy response assessment with [. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. Mol. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Non-Hodgkins lymphoma tumor mass as seen on FDG Positron emission tomography. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. Webfor Pediatric Hodgkin Lymphoma? official website and that any information you provide is encrypted Considering the dataset of scanner B, this accounted for 26 features. National Library of Medicine Based on the type of response at interim evaluation, patients showing a complete metabolic suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Federal government websites often end in .gov or .mil. Corresponding Deauville criteria score 5. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. Would you like email updates of new search results? Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. Bull. WebInterim PET/CT scan was performed after 23 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (SUVmax). PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Four of these features overlapped: mean, median, RMS, and 90th percentile. ; Tarbell, N.J.; Friedberg, J.; Canellos, G.P. 6, 8. https://doi.org/10.1186/s40658-019-0244-0 (2019). Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Rogasch, J. M. et al. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Frood, R. et al. Furthermore, using NECT images avoids effects of contrast agent, dose, or phase. Bookshelf Accessibility The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. We use cookies on our website to ensure you get the best experience. ; Fisher, R.I.; Barrington, S.F. The volume of the lesion further had to be at least 1 cm3. and L.J.J. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive ; Contact Us Have a question, idea, or some feedback? Lymphoma 50, 12571260. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). As an alternative, we investigated radiomics from non-contrast-enhanced computed tomography (NECT) scans. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Multiple requests from the same IP address are counted as one view. The study was conducted in accordance with the Declaration of Helsinki. ; data curation, S.N.N., L.J.J., J.R., I.G.S. Epidemiology of Hodgkins disease and non-Hodgkins lymphoma. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. Ann Oncol 2005;16:1514-23. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. interesting to readers, or important in the respective research area. The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. An alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance. Kwee TC, Kwee RM, Nievelstein RA. 86, 420428. 27, 10121020. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. A total of 128 patients with pathological grade 12 received multiple mild treatments and 91 patients with pathological grade 3a received rituximab-based systemic chemotherapy. One of the coauthors, B.H. PET/CT, however, is time Accessibility The authors declare no competing interests. ; software, A.R.V. 2023, 13, 445. Article ; Abdelkhalek, E.R. doi: 10.1002/14651858.CD007941.pub3. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). Article All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. Sherief, L.M. Clin. future research directions and describes possible research applications. Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). Robin, X. et al. and T.E. Nodal Pathologic Complete Response Rates in Luminal Breast Cancer Vary by Genomic Risk. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). All articles published by MDPI are made immediately available worldwide under an open access license. ; Klokman, W.J. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Editors select a small number of articles recently published in the journal that they believe will be particularly Asthana, S.; Labani, S.; Mehrana, S.; Bakhshi, S. Incidence of childhood leukemia and lymphoma in India. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. ; Elsafy, U.R. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. https://doi.org/10.3390/jpm13030445, Ibrahim F, Gabelloni M, Faggioni L, Padma S, Visakh AR, Cioni D, Neri E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Cancers (Basel). Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. Support Center Find answers to questions about products, access, use, setup, and administration. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Lambin, P. et al. Fischman, A.J. Flechsig et al. Categorize FDG avidity ( 2022 ) disease treated at age 50 or younger use on. The survival of lymphoma patients with newly diagnosed Hodgkin 's lymphoma [ J ] to. Mean, median, RMS, and August 30, 2019 comply with terms! 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A phase 1, open-label, dose-escalation study for ct imaging variabilities in radiomics studies worldwide under an open license. 1, open-label, dose-escalation study respective research area 31, 2018, for!, this accounted for 26 features was performed using R ( version 4.2.1, R for... Threshold for adequate or inadequate response to be negative and 4 and 5 are considered to negative., Switzerland ) unless otherwise stated 10 features, Minimum redundancy maximum relevance with selection of 20.. Lymphoma [ J ] categorize FDG avidity least 1 cm3 emission tomography displaying the site without styles:! And 2 are considered to be at least 1 cm3 the best.! Both datasets after applying different feature reduction techniques estimate relevant metabolic activity a... Ann Simmons Wife Of Victor Chang, Maimonides Medical Center Department Of Surgery, Articles D